Apposit designed, developed and implemented a multi-site patient database for advanced clinical monitoring (ACM) of antiretroviral treatment (ART) of HIV/AIDS patients in Ethiopia. This system is used to consolidate ACM study patient’s data collected from seven Ethiopian university hospitals and provides data analysis, extraction and reporting tools. In addition, the system is used to manage ACM patient’s laboratory specimen storage, request for specimen analysis and collection of laboratory test results on test performed on each patient’s specimen. The system is being used by the Ethiopian Health and Nutrition Research Institute (EHNRI), the Ethiopian Science and Technology Commission, the United States Centers for Disease Control and Prevention (CDC), The Johns Hopkins University (JHU) and other researchers.